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Signal Transduction and Regulation
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Signal transduction
pathways regulate diverse processes in cell division,
development, and differentiation. These pathways often
involve cascades of protein kinases and their activation
typically results in changes in gene expression and cellular
activity.
Signal transduction research in the Department
spans many fields: cell cycle regulation, TGF-b signalling,
pathogen-associated molecular patterns, signalling in the
central nervous system, regulation of glucose and ion
transport, signalling in blood platelets, and structural
aspects of signalling molecules.
Our researchers make use
of a number of model systems to relate the biochemical
properties of signalling pathways to cellular function,
including bacteria, yeast, and mammalian cells.
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Smad4 transcription factor changes from a generalized distribution (left) to a nuclear localization (right) following addition of TGFbeta.
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currently doing research in this area: |
K. Adeli
Molecular and Cellular Biology of Lipoprotein Metabolism
Hospital for Sick Children, Research Institute, Room 3653
416-813-8682 khosrow.adeli@sickkids.ca
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S.
Angers
Functional proteomics of Wnt and Hedgehog signalling. Mechanisms of ubiquitination
by Cullin-4 E3 ligases.
Leslie Dan Pharmacy Building, Room 901
416-978-4939 stephane.angers@utoronto.ca
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L. Attisano
Signalling by TGF beta and Wnt in Development and Disease
Donnelly Centre for Cellular and Biomolecular Research Room 1008
416-946-3129 liliana.attisano@utoronto.ca
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G.W. Brown
DNA Replication, DNA Damage and Genome Instability
Donnelly Centre for Cellular and Biomolecular Research, Room 1206
416-946-5733
grant.brown@utoronto.ca
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J.
Forman-Kay
Protein Structure, Dynamics and Folding by NMR Method
Hospital for Sick Children, Research Institute, Room 3401
416-813-5358 forman@sickkids.ca
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S. Grinstein
Biological Membranes and Ion Transport
Hospital for Sick Children, McMaster Building, Room 5006
416-813-5727 sga@sickkids.ca
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J.W. Gurd Professor Emeritus
Effect of Stress on the Molecular Composition of Excitatory Synapses of the Central Nervous System
Centre for the Neurobioloy of Stress, Division of Life Science, University of
Toronto at Scarborough
416-287-7410 gurd@utsc.utoronto.ca
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A. Klip
Regulation of Glucose Transport and Membrane Proteins in Muscle
Hospital for Sick Children, McMaster Building, Room 5004B
416-813-6392 amira@sickkids.ca
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J. Parkinson
Comparative Genomics and Computational Systems Biology
TMDT Building, East Tower 15th Floor, Rm 15-703
416-813-5746 jparkin@sickkids.ca
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M.L. Rand
Function and Signal Transduction in Blood Platelets
Hospital for Sick Children, Room 7019D
416-813-7764 margaret.rand@sickkids.ca
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D. Rotin
Biochemical and biological functions of the ubiquitin system
Hospital for Sick Children,TMDT-MaRS, Room 11-305
416-813-5098 drotin@sickkids.ca
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F. Sicheri
Structural Biology of Eukaryotic Signal Transduction
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
416-586-8471 sicheri@lunenfeld.ca
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J.M. Segall Professor Emeritus
Regulation of Gene Expression
Medical Sciences Building, Room 5336
416-978-4981 j.segall@utoronto.ca
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A. Wilde
Cell Division and Oogenesis
Medical Sciences Building, Room 4377
416-946-7714 andrew.wilde@utoronto.ca
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