University of Toronto Biochemistry

Gene Expression and Development

The fate of a cell is in large part determined by a specific pattern of gene expression. This pattern is in part directed by signalling molecules that modulate a variety of regulatory cascades.

Our research is devoted to understanding the molecular intricacies that are involved in interpretation of intercellular and intracellular regulatory signals and dictating a cell-type specific pattern of gene expression. Our interests include elucidation of the mechanisms that modulate chromatin assembly and structure; understanding the role of DNA-binding transcription factors in controlling differential transcription of a gene; and investigation of specialized regulatory processes, such as translational control.

Specific research programs range from studies of connective tissue function to regulation of embryonic development in flies; from structure-function studies of chromatin modifying enzymes to identification of novel regulatory molecules.

Faculty currently doing research in this area:

K. Adeli Molecular and Cellular Biology of Lipoprotein Metabolism Hospital for Sick Children, Research Institute, Room 3653 416-813-8682 khosrow.adeli@sickkids.ca	C.J. Ingles Professor Emeritus Molecular Mechanisms Regulating Transcription of RNA in Eukaryotic Cells Banting & Best Department of Medical Research, Rooms 103/107 416-978-7400 cj.ingles@utoronto.ca
P.N. Lewis Chromatin Structure and Function Medical Sciences Building, Room 5334 416-978-6759 peter.lewis@utoronto.ca	A. Palazzo Mechanism of mRNA Export and Localization Medical Sciences Building, Room 5242 416-978-7450 alex.palazzo@utoronto.ca
H. Schachter Professor Emeritus Structure and Synthesis of Glycoproteins Hospital for Sick Children, Research Institute, Room 3427B 416-813-5915 harry@sickkids.on.ca	J.M. Segall Professor Emeritus Regulation of Gene Expression Medical Sciences Building, Room 5336 416-978-4981 j.segall@utoronto.ca
C. Smibert Translational Regulation During Development Medical Sciences Building, Room 5344 416-946-5538 c.smibert@utoronto.ca	J. Sodek Biochemistry of Connective Tissue FitzGerald Building, Room 234 416-978-6624 jaro.sodek@utoronto.ca

Department of Biochemistry
University of Toronto
Toronto, Canada

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