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Molecular Medicine
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The biochemical
and structural characteristics of disease-associated proteins
in their native and mutated forms have been a major focus
of several investigators in the Department.
For the proteins
associated with cystic fibrosis, mitochondrial disease,
cancer and a wide variety of metabolic disorders, physical,
biochemical and catalytic studies are carried out to derive
a picture of both normal and abnormal structure and function.
Future studies are targeted at finding techniques and
methodologies to correct the abnormal cellular function
derived from the behaviour of the mutant protein.
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currently doing research in this area: |
K. Adeli
Molecular and Cellular Biology of Lipoprotein Metabolism
Hospital for Sick Children, Research Institute, Room 3653
416-813-8682 khosrow.adeli@sickkids.ca
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D.M. Clarke
Canada Research Chair in Membrane Biology
Structure and Function of Membrane Transport Proteins
Medical Sciences Building, Room 7342
416-978-1105 david.clarke@utoronto.ca
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S.
O. Kelley
Molecular and cellular sensors
Medical Sciences Building, Room 5326
416-978-4415 shana.kelley@utoronto.ca
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M.F. Manolson
Assembly, Targeting, and Control of Proton Pumping V-ATPases
Faculty of Dentistry, 124 Edward Street Room 403
416-979-4900 #4392 m.manolson@utoronto.ca
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A. Marks Professor Emeritus
Tumor Biology and Neurobiology
Banting & Best Department of Medical Research, Room 105
416-978-4075 alexander.marks@utoronto.ca
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R. Melnyk
Bacterial Pathogenesis: Molecular Mechanisms and Therapeutic Approaches
Hospital for Sick Kids, Room 3203A
416-813-7654 x28557 roman.melnyk@sickkids.ca
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B.H. Robinson Professor Emeritus
Inborn Error in Man: Chronic Childhood Lacticacidemia
Hospital for Sick Children, Research Institute, Room 9146C
416-813-5989 bhr@sickkids.on.ca
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F. Sicheri
Structural Biology of Eukaryotic Signal Transduction
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
416-586-8471 sicheri@lunenfeld.ca
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Boris Steipe
Bioinformatics
Medical Sciences Building, Room 5271
416-946-7741 boris.steipe@utoronto.ca
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