The main goal of our lab is to understand how interactions among a special class of proteins, called membrane proteins, produce either healthy or diseased cells at a systems level. Membrane proteins, which make up approximately one-third of all proteins in any cell, are responsible for a variety of processes, making them attractive therapeutic targets for many diseases such as hypertension, diabetes, neurological disorders, and various types of cancer.
We use a combination of molecular, cellular, and
high-throughput proteomic approaches.
Current research in our lab involves
two powerful technologies that we
have developed for use in the study
of integral membrane proteins:
Igor Stagljar was born in Zagreb, Croatia and educated at the University of Zagreb where he obtained a BSc degree in Molecular Biology. He then moved to Switzerland where he received his PhD degree in Molecular Biology from the Swiss Federal School of Technology (ETH) in Zurich. Afterwards he undertook two post-doctoral positions at the University of Zurich, the first working on RNA polymerase II transcription in mammals, and the second position involved working on various aspects of DNA replication and repair in yeast.
In 2001, Igor was a visiting scientist at the University of Washington in Seattle, USA, where he worked in the lab of Dr. Stanley Fields, the inventor of the yeast two-hybrid technology. From 2002 to 2005, Igor maintained an Assistant Professor position at the University of Zurich.
In the summer of 2005, Igor moved to Canada where he accepted an Associate Professor position (with tenure) at the Department of Biochemistry and Department of Molecular Genetics at the University of Toronto. In 2010, Igor was promoted to the rank of full Professor at the University of Toronto. His lab is located in the Donnelly Centre, a cutting-edge, interdisciplinary research institute in the heart of Toronto's research district.
Igor is the recipient of several national and international science awards, and is a member of the Croatian Academy of Arts and Sciences. In addition, he is a member of the Editorial board of BioTechniques, Molecular Genetics and Genomics, BMC Biotechnology, Journal of Molecular Biology and Biochemical and Biophysical Research Communications. Lastly, Igor is co-founder of Dualsystems Biotech, and is currently involved in co-founding another company based on the Mammalian Membrane Two-Hybrid (MaMTH) technology.
Lab group photo, November 2014