Seminars Sponsored by the Training Program

Current Seminar Series
Thursdays at 12pm

click here for previous seminars
For more detailed information click here on recent seminars and here for upcoming seminars.

2015

February 19 MSB 4171		Ryan Hibbs UT Southwestern Medical Center, Dallas	Ligand-gated ion channel architecture and mechanism
February 26 MSB 4171		Daniel Hebert University of Massachusetts	Glycoprotein folding and quality control in the ER
March 26 MSB 4171		Benjamin Glick University of Chicago	Topic TBA
April 9 MSB 4171		Hashim M Al-Hashimi Duke University School of Medicine	Topic TBA
May 14 MSB 4171		Lynette Cegelski Stanford University	Topic TBA
June 18 MSB 4171		Ben Schuler University of Zurich	Topic TBA

2014

March 3 MSB 4171 *Monday, 11AM*		Russell Bishop McMaster University	New roles for PagP in bacterial evasion of host immune defenses
March 27 MSB 4279		Gianluigi Veglia University of Minnesota	Allosteric Regulation of the Sarcoplasmic Reticulum Ca2+-ATPase by Phospholamban and Sarcolipin using Solid-State NMR Spectroscopy
April 9 CCBR Red Room		Joan-Emma Shea University of California, Santa Barbara	Effect of surfaces in modulating protein folding and aggregation mechanisms
April 23 MSB 4171		Phoebe A. Rice The University of Chicago	Site specific DNA recombination and transposition in 3D
May 1 MSB 4279		Philip W. Fowler University of Oxford	Voltage-gated potassium ion channels are frustrated: insights into protein dynamics from molecular dynamics simulations
July 14 CCBR Red Room		Steven Plotkin University of British Columbia	Protein misfolding in an incurable neurodegenerative disease: Connecting theory and experiment
October 23 MSB 4171		Aymelt Itzen AG Proteinchemie Technische Universität München	Modulation of small GTPase activities by pathogenic bacteria
November 13 MSB 4171		Charalampos (Babis) Kalodimos Rutgers University	Molecular Chaperones in Action
December 10 MSB 4171		Flemming Hansen University College, London UK	Ions, loops, and side chains: Dynamic regulations of histone deacetylases (HDACs)
December 11 MSB 4171		James Bardwell Howard Hughes Medical Institute	Discovery of new chaperones

2013

January 31 MSB 4171		Carolyn Sevier Cornell University	Pathways for oxidative protein folding and redox homeostasis in the endoplasmic reticulum (ER)
February 7 MSB 4171		Jeffrey L. Brodsky University of Pittsburgh	Protein conformational diseases and ER associated degradation (ERAD): Lessons from model systems
February 28 MSB 4171		Tanja Kortemme	Molecular Design and Functional Specificity - from Proteins to Cells
March 7 MSB 4171		Scott Prosser (Program Mentor)	"The Elusive Dry Molten Globule Folding Intermediate. Fact or Fiction?" 19F NMR Studies of Folding and Aggregation Behaviour of Soluble Proteins
March 14 MSB 4171		Robert K. Yu, PhD, MedScD Georgia Health Sciences University	Glycobiology of neural stem cells in health and disease
March 21 MSB 4171		Kevin Gardner	Environmentally-switched protein/protein interactions: Uses in natural and artificial signaling
March 25 MSB 4279 (Monday)		Eric Masse University of Sherbrooke	Small RNAs regulating mRNA stability and translation in E. coli
April 25 MSB 4171		Chuck Sanders Vanderbilt University	The Structure and Cholesterol Binding Properties of the Amyloid Precursor Protein Offer Insight into The Etiology and Prevention of Alzheimer's Disease
May 2 MSB 4171		Walid Houry (Program Mentor)	R2TP: A novel chaperone-like complex involved in multiple cellular pathways
October 10 MSB 4171		Nikolay V. Dokholyan University of North Carolina	Understanding the etiology of the Lou Gehrig’s disease
November 7 MSB 4171		Paul LaPointe University of Alberta	Deconstructing the Hsp90 Cycle: Interplay between co-chaperone regulation and drug sensitivity
November 14 MSB 4171		Sophie Jackson University of Cambridge	Protein Knots: Which? Where? How and Why?
November 15 MSB 4171		Jason C. Young McGill University	Tuning of Hsp70 Function by Co-Chaperones
November 21 MSB 4171		Peter E. Wright The Scripps Research Institute	Functional interactions of intrinsically disordered proteins in dynamic signaling networks
December 12 MSB 4171		Anthony Schryvers	Bacterial Receptors for Host Transferrin and Lactoferrin: Targets for Vaccines

 

Previous Seminars

"Conditional regional genetic ablation of a 26S proteasomal ATPase gene in the mouse brain recapitulates features of Parkinson’s disease and dementia with Lewy bodies" John Mayer University of Nottingham Medical School Queen's Medical Centre February 18, 2010

Seminars in Previous Years

	2012
	February 23	John Glover (Program Mentor)	Chaperone-dependent remodelling of the yeast prion [PSI+]
	March 15	Tobin R Sosnick University of Chicago	Protein folding: Prediction, experiment, and light-controllable designs
	March 22	Elizabeth Vierling University of Massachusetts	Small HSPs capturing unfolding proteins
	April 26	Dieter H. Wolf University of Stuttgart	Protein Quality Control and Degradation of Misfolded Proteins by the Ubiquitin-Proteasome System
	April 27	Jean-Luc Popot CNRS & Université Paris, Institut de Biologie Physico-Chimique	Applications of amphipols to membrane protein studies (and some new insights into membrane protein folding)
	May 10	Charles Deber (Program Mentor)	Micelles as membrane-mimetics for membrane protein folding
	May 17	Daniel R. Southworth University of Michigan	The Decision to Fold or Degrade: Mechanisms of the Hsp90 and Hsp70 Molecular Chaperone Machinery
	November 1	Dr. Todd Yeates UCLA	Giant protein assemblies in nature and by design: bacterial microcompartment organelles and engineered protein cages
	November 15	Dr. Daniel Jay Tufts University School of Medicine	CALI-based functional screen reveals extracellular role for Hsp90 in cancer invasion: mechanism, export and future directions
	November 22	Dr. Reinhart Reithmeier (Program Mentor)	A transport tunnel in the cytosolic domain of Band 3?
	2011
	January 13	Chris Kaiser MIT	Control of the Redox environment of the Endoplasmic Reticulum
	January 26	Kenneth Evans Ontario Cancer Biomarker Network, MaRS	Quantitative proteomics and its application for the identification of disease markers
	February 3	Neil Cashman University of British Columbia Prionet Canada	The Prion Principle Redux
	February 10	Bill Balch Scripps Research Institute	Proteome Balance: Proteostasis and Managing Human Healthspan
	March 9	Young-Hwa Song Research Center Borstel and EMBL-Hamburg	Novel molecular insights into the potent T-cell antigen ESAT-6/CFP-10, the major factor of the old tuberculin skin test
	March 31	Gergely Lukacs McGill University	ΔF508 CFTR folding defect; signaling degradation at the ER and cell surface
	April 7	Bhushan Nagar McGill University	Structural basis for 5' nucleotide recognition by Argonaute Proteins
	April 21	Noboru Ishiyama (Trainee) Ikura Lab	Molecular insights into cadherin/catenin-mediated cell-cell adhesion
	May 5	Keith Willison Institute of Cancer Research, London	Structure-function analysis of the eukaryotic cytosolic chaperonin CCT: folding actin uphill into a spring-like state
	May 12	Rachel Klevit University of Washington	Taming the beast: Structural biology of the small heat shock protein, aB-crystallin
	June 23	Robert Konrat University of Vienna	Structural biology of unstructured proteins
	July 28	John Baenziger University of Ottawa	Uncoupling binding from gating in the nicotinic acetylcholine receptor: a possible role for lipids modulating synaptic function
	September 22	Valerie Daggett University of Washington	Dynameomics: The effect of context on protein folding
	October 13	David A. Harris Boston University School of Medicine	Prion Protein Neurotoxicity
	October 27	Erich Bornberg-Bauer University of Münster	Evolutionary dynamics and adaptive benefits of emergence and modular rearrangements of protein domains
	October 27	Aaron D. Gitler University of Pennsylvania	High-throughput genetic screens to define mechanisms of human neurodegenerative diseases
	December 1	Filip Van Petegem University of British Columbia	Calcium and disease:  Structural investigations of Ryanodine Receptors and voltage-gated sodium channels
	December 2	Luis A. Rokeach Université de Montréal	THE ER CHAPERONE CALNEXIN: Dual roles in the regulation of apoptosis
	December 8	Steven E Ealick Cornell University	Enzyme suicide and cofactor cannibalism for the sake of thiamin biosynthesis in yeast
	2010
	January 28	Trevor Moraes (Dept of Biochemistry, UofT)	The Surface Exposed Bacterial Lipoprotein TbpB Facilitates Iron Acquisition from Transferrin
	February 11	Reinhart Reithmeier (Program Mentor)	Trafficking defects in red cell and kidney anion exchanger membrane glycoproteins linked to disease
	February 18	John Mayer (University of Nottingham Medical School, Queen's Medical Centre)	Conditional regional genetic ablation of a 26S proteasomal ATPase gene in the mouse brain recapitulates features of Parkinson’s disease and dementia with Lewy bodies
	March 4	Michel Leroux Department of Molecular Biology and Biochemistry Simon Fraser University	Two step pathway for ciliogenesis: early role for transition zone-localised ciliopathy proteins
	March 25	Bil Clemons (Department of Biochemisty, Caltech)	Structural insights into the targeting of tail-anchored membrane proteins
	May 6	Stewart Loh (Department of Biochemistry & Molecular Biology, SUNY Upstate Medical University )	Design of protein-based molecular switches
	June 3	Gary Pielak (Department of Chemistry, University of North Carolina at Chapel Hill )	Macromolecular Crowding & Protein Chemistry: Views from Inside & Outside Cells
	July 8	Walid Houry (Program Mentor)	The role of amino acid decarboxylases in the bacterial acid stress response
	July 15	Patrick G. Hogan ( La Jolla Institute for Allergy & Immunology, La Jolla, California )	Signalling via ORAI1 calcium channels
	August 30	Joaquin Ortega (Department of Biochemistry and Biomedical Sciences and MG. DeGroote Institute for Infectious Diseases Research, McMaster University)	Understanding Ribosome Assembly: the Structure of Immature 30S Subunits Revealed by Cryo-electron Microscopy
	September 30	Michael S. Kay University of Utah School of Medicine	Design of a Potent D-peptide HIV-1 Entry Inhibitor with a Strong Barrier to Resistance
	October 7	James Fraser California Institute for Quantitative Biosciences (QB3), University of California, San Francisco	Hidden alternate enzyme conformations essential for catalysis
	October 21	Alan R. Davidson Program Mentor	The Importance of Peptide-Binding Specificity for the Function of SH3 Domains
	November 18	A. Keith Dunker Department of Biochemistry and Molecular BiologyIndiana University School of Medicine	Protein Intrinsic Disorder and Cell Signaling
	December 16	Frank Sicheri	Structural Principles of Protein Kinase Regulation
	2009
	February 19	Bob Ford (University of Manchester )	Membrane transporters: What the ATP-binding cassette family can tell us
	March 12	Daniel Gewirth (SUNY Buffalo)	New Insights into the Mechanism of Hsp90 Chaperones: The Structure of GRP94
	June 1-5	Third CIHR Strategic Training Program International Symposium on Protein Folding: Principles and Diseases was held from June 1st - 5th, 2009 in conjunction with the 52nd Annual Meeting of the CSBMCB on Protein Folding: Principles and Diseases
	October 23	Rafael Bruschweiler (Florida State University)	From Protein Dynamics to Thermodynamics by NMR, MD, X-ray and Simple Models
	November 12	Alexander Palazzo (Dept of Biochemistry, UofT)	Specialized Nuclear Export of mRNA Encoding Secreted and Mitochondrial Proteins
	2008
	March 20	Tony Dean (University of Minnesota )	A tale of Two Enzymes
	March 25	Jacob Anglister (Weizmann Institute Israel)	HIV-1 V3 structures suggest a mechanism for the virus phenotype conversion
	March 27	Gary S. Shaw (University of Western Ontario)	Folding of the Calcium-binding S100 Proteins
	April 3	Louis Delbaere (University of Saskatchewan)	Structure/ function Studies of Phosphoenolpyruvate Carboxykinase
	September 4	Lawrence McIntosh (University of British Columbia )	Where is the proton? Dissecting the pH-dependent enzymatic mechanisms of model glycosidases by NMR spectroscopy and neutron crystallography
	2007
	January 16	Ulrich Hartl (Max Planck Institute)	Understanding chaperone-assisted protein folding
	March 15	Charles Deber (Program Mentor)	Decrypting the determinants for membrane protein folding
	April 5	Martin McGavin (Program Mentor)	Orchestral Maneuvers: Intricacies of Protease Secretion and Activation in Staphylococcus aureus
	April 10	Angel Garcia (Rensselaer Polytechnic Institute)	Theoretical Studies of Pressure Effects on Folding/Unfolding of Proteins and Nucleic acids
April 19	Huan-Xiang Zhou (Florida State University)	Protein Interactions: Structure, Energetics, and Kinetics
April 26	Gerold Schmitt-Ulms (Program Mentor)	Towards in vivo analyses of interactomes and protein complex topologies
May 24	Koreaki Ito (Kyoto University)	Molecular mechanisms and structural grounds of protein-disulfide-bond generation
May 30	Lynn Zechiedrich (Baylor College of Medicine)	Genome entanglement and resolution; A matter of life, death, and evolution
June 7	Alan Davidson (Program Mentor)	New Insights into Protein Binding by SH3 Domains
October 4	Radhey S. Gupta (McMaster University)	Genome Sequences and the Outlines of Bacterial Evolution
November 8	Irina Gutsche (UJF-EMBL-CNRS France)	Electron microscopy - from images to structure
November 15	Wolfgang Peti Manning (Brown University)	Intrinsically Unstructured Proteins Provide Specificity for Protein Phosphatase 1 Regulation
November 29	Steven Plotkin (University of British Columbia)	Protein folding as a system for biologically-inspired physics
2006
January 12	Andrew Woolley (Program Mentor)	Designing Photo-controlled Peptides and Proteins
February 2	Susan Michaelis (Johns Hopkins Sch. Med.)	From A to Z: Yeast A-factor, Mammalian Lamin A and Aging - The Zmpste24 Protease Connection
February 16	Catherine Michaux (PDF)	A Method to Refold Proteins from SDS
March 30	Reed Wickner (NIH)	Yeast Prion Diseases: Infection by Amyloid of Recombinant Ure2p and Scrambling of Prion Domains
April 20	Régis Pomès (Program Mentor)	Molecular Basis of Elastin Self Assembly and Elasticity
May 12	John Markley (University of Wisconsin)	Protein Structures of Biomedical Interest Solved at the Center for Eukaryotic Structural Genomics
May 25-26	2nd CIHR Strategic Training Program International Symposium on Protein Folding: Principles and Diseases
September 18	Seishi Shimizu (University of York, UK)	Protein Stability in the Presence of Cosolvents
October 12	Martin Latterich (McGill University)	The role of p97 in Ubiquitin-dependent and Independent Pathways
November 23	JoAnne McLaurin (Program Mentor)	Development of a Small Molecule Therapy for Alzheimer's Disease
November 30	David Williams (Program Mentor)	Calnexin and calreticulin: multifunctional glycoprotein folding machines
2005
January 27	Charles Deber (Program Mentor)	Hydrogen Bonds and Human Disease: Misfolding of Membrane Proteins
February 24	Arash Zarrine-Afsar (Program PhD Trainee)	Local Structure Propensity in Protein Folding
March 17	Russell Bishop (Program Mentor)	Modulation of the PagP hydrocarbon ruler by site-specific chemical methylation: subtle structural changes dramatically affect protein stability
April 30	Alasdair C. Steven (NIH-NIAMS)	From Unfolded to Misfolded: Mechanisms of Prionogenesis and Infection in Yeast
May 19	Walid Houry (Program Mentor)	The Construction of a Protein Unfolding and Degradation machine: The ClpXP System
June 9	Martin J. McGavin (Program Mentor)	Virulence Factor Secretion and Maturation in Staphylococcus aureus
July 28	Christine Queitsch (Harvard University)	Chaperone Hsp90 as a molecular mechanism of genetic and environmental canalization
September 29	Janice Robertson (Program Mentor)	Peripherin Abnormalities in ALS (Lou Gehrig's Disease)
October 20	Matthew Cordes (University of Arizona)	The Remarkable Structural Evolution of Cro Proteins
December 1	Robert Woody (Colorado State University)	Predicting Protein Circular Dichroism Spectra
2004
January 22	Fred Keeley (University of Toronto)	Hydrophobic Self-assembly of Elastin Polypeptides into Elastomeric Polymers
April 1	Stefan Wallin (Program PDF Trainee)	Physical Modeling of Protein Folding
May 27	Walid Houry (Program Mentor)	Navigating the Chaperone Network in the Cell
June 3-4	First CIHR Strategic Training Program International Symposium on Proteins: Structure, Folding and Disease
September 30	Elizabeth M. Meiering (University of Waterloo)	Protein Folding and Misfolding: Implications for Biology, Industry and Disease
December 2	Johnny Tkach, Monika Niggemann and Ronnie Lum (Student and PDF Trainees)	Activation of PEP Carboxykinase by Ca2+
2003
January 30	Tigran V. Chalikian (Program Mentor)	Combined Volumetric and Calorimetric Characterizations of the Thermodynamics of Protein Recognition
March 6	Charles Deber (Program Mentor)	A Third Stage in the Two-Stage Model for Membrane Protein Folding?
May 15	David Westaway (Program Mentor)	Transgenic Approaches to the Analysis of Prion and Alzheimer Disease Proteins
June 23	Lila Gierasch (U. Mass., Amherst)	Folding of a Predominantly beta-Sheet Protein In Vitro and In Vivo
July 24	Hughes Goldie (University of Saskatchewan)	Activation of PEP Carboxykinase by Ca2+
October 16	Rishi Rakhit (Program PhD Trainee)	Splitting Pairs: Conformational Changes of SOD1 in ALS
2002
January 31	Avi Chakrabartty (Program Mentor)
March 7	Julie Forman-Kay (Program Mentor)
April 4	Walid Houry (Program Mentor)
May 23	Tigran Chalikian and Rana Filfil (Program Mentor and Trainee)
September 12	John Glover (Program Mentor)
November 7	Boris Steipe (Program Mentor)	An Engineered Functional Biomolecular Nanoassembly
2001
May 3	Tigran Chalikian Program Mentor
June 7	Régis Pomès Program Mentor
October 4	Charles Deber Program Mentor
November 1	Hue Sun Chan Program Mentor
December 13	Alan Davidson Program Mentor