McQuibban Lab

Department of Biochemistry, University of Toronto

Molecular mechanisms of mitochondrial membrane dynamics and their role in cell function and disease
artwork courtesy of Ina Schuppe-Koistinenhttp://www.nick-lane.net/Scientific%20Art.htmshapeimage_3_link_0

Publications


  1. BulletChan, EY & McQuibban, GA. The mitochondrial rhomboid protease: its rise from obscurity to the pinnacle of disease-relevant genes. BBA. Dec. 2013 Pubmed


  1. BulletShanbhag, R., Shi, G., Rujiviphat, J., McQuibban, G.A. (2012) The emerging role of proteolysis in mitochondrial quality control and the etiology of Parkinson’s disease. Parkinsons Dis. 382175. Pubmed


  1. BulletMcQuibban, GA & Bulman, DE. (2011) The PARLance of Parkinson disease. Autophagy, July 7 Pubmed


  1. BulletShi G, Lee JR, Grimes DA, Racacho L, Ye D, Yang H, Ross O, Farrer M, McQuibban GA, Bulman DE. (2011) Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease. Hum Mol Genet. Pubmed



  4. BulletMcQuibban GA, Joza N, Megighian A, Scorzeto M, Zanini D, Reipert S, Richter C, Schweyen RJ, Nowikovsky K. (2010) A Drosophila mutant of LETM1, a candidate gene for seizures in Wolf-Hirschhorn syndrome. Hum Mol Genet. Mar 15;19(6):987-1000.  Dec 21. Pubmed



  7. BulletRujiviphat J, Meglei G, Rubinstein JL, McQuibban GA. (2009) Phospholipid association is essential for the dynamin-related protein Mgm1 to function in mitochondrial membrane fusion. J Biol Chem. Aug 24. Pubmed



  10. BulletMeglei G, McQuibban GA. (2009) The Dynamin-Related Protein Mgm1p Assembles into Oligomers and Hydrolyzes GTP To Function in Mitochondrial Membrane Fusion. Biochemistry. Feb 10. Pubmed



  13. BulletYu L, Lopez A, Anaflous A, El Bali B, Hamal A, Ericson E, Heisler LE, McQuibban A, Giaever G, Nislow C, Boone C, Brown GW, Bellaoui M. (2008) Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells. PLoS Genet.  Nov;4(11):e1000284. Pubmed



  16. BulletWhitworth AJ, Lee JR, Ho VMW, Flick R, Chowdury R, McQuibban GA. (2008) Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson’s disease factors Pink1 and Parkin. Dis. Model. Mech. Sep 19;1:168-174. Pubmed



  19. BulletYang Y, Ouyang Y, Yang L, Beal MF, McQuibban A, Vogel H, Lu B. (2008) Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci U S A. May 13;105(19):7070-5. Pubmed



  22. BulletMcQuibban GA, Lee JR, Zheng L, Juusola M, Freeman M. (2006) Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function. Current Biology. May 23;16(10):982-9. Pubmed



  25. BulletMcQuibban GA, Saurya S, Freeman M. (2003) Mitochondrial membrane remodelling regulated by a conserved rhomboid protease. Nature. May 29;423(6939):537-41 Pubmed



  28. Pubmed all McQuibban papers

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