(Cancer) Genomics via (Sub)Optical Mapping

The dream of a powerful integrated computational framework, only hinted at in Ibn Sina's Canon, can now be fulfilled at a global scale as a result of many recent advances: foundational advances in statistical inference; hypothesis-driven experiment design and high resolution single-molecule-single cell tech-nologies. We will focus on an application centered on cancer - "the emperor of all maladies.” The topics this talk will cover include: Probabilistic causation, Causal analysis of Cancer genome data, Kernel based methods for survival analysis, Improved single-cell/single-molecule data via SubOptical Mapping, CHA (Cancer Hybrid Automata) and Therapy design, Immuno-therapy, etc. Professor Bud Mishra is a professor of computer science and mathematics at NYU's Courant Institute of Mathematical Sciences, professor of computer sci-ence and engineering at NYU’s Tandon School of Engineering, professor of human genetics at Mt. Sinai School of Medicine, and a professor of cell biology at NYU School of Medicine. He founded the NYU/Courant Bioinformatics Group, a multi-disciplinary group working on research at the interface of com-puter science, applied mathematics, biology, biomedicine and bio/nano-technologies. Prof. Mishra has a degree in Physics from Utkal University, in Electronics and Communication Engineering from IIT, Kharagpur, and MS and PhD degrees in Computer Science from Carnegie-Mellon University. He has industrial experience in Computer and Data Science (Pypestream, brainiad, Genesis Media,Tartan Laboratories, and ATTAP), Finance (Instadat, Tudor Investment and PRF, LLC), Robotics and Bio- and Nanotechnologies (InSilico, Seqster, Abraxis, OpGen, and Bioarrays). He is the author of a textbook on algorithmic algebra and more than two hundred archived publications. He has advised and mentored more than 35 graduate students and post-docs in the ar-eas of computer science, robotics and control engineering, applied mathemat-ics, finance, biology and medicine. He is an inventor of Optical Mapping and Sequencing (SMASH), Array Mapping, Copy-Number Variation Mapping, Model Checker for circuit verification, Robot Grasping and Fixturing devices and algorithms, Reactive Robotics, and Nanotechnology for DNA profiling. He is a fellow of IEEE, ACM and AAAS, a Distinguished Alumnus of IIT-Kharagpur, and a NYSTAR Distinguished Professor. From 2003-2006, he held adjunct professorship at Tata Institute of Fundamental Research in Mum-bai, India. From 2001-04, he was a professor at the Watson School of Biologi-cal Sciences, Cold Spring Harbor Lab; currently he is a QB visiting scholar at Simons Center for Quantitative Biology, Cold Spring Harbor Lab.